3ME6

Crystal structure of cytochrome 2B4 in complex with the anti-platelet drug clopidogrel

3ME6 の概要

• エントリーDOI: 10.2210/pdb3me6/pdb
• 関連するPDBエントリー: 1PO5 1SUO 2BDM 2Q6N 3G5N 3G93 3KW4
• 分子名称: Cytochrome P450 2B4, PROTOPORPHYRIN IX CONTAINING FE, Clopidogrel, ... (4 entities in total)
• 機能のキーワード: p450, cytochrome p450 2b4, monooxygenase, oxidoreductase, membrane protein, cyp 2b4, cyp lm2
• 由来する生物種: Oryctolagus cuniculus (rabbit)
• 細胞内の位置: Endoplasmic reticulum membrane; Peripheral membrane protein: P00178
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 220429.56

構造登録者

Gay, S.C.,Roberts, A.G.,Maekawa, K.,Talakad, J.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R. (登録日: 2010-03-31, 公開日: 2010-09-15, 最終更新日: 2023-09-06)

• 主引用文献: Gay, S.C.,Roberts, A.G.,Maekawa, K.,Talakad, J.C.,Hong, W.X.,Zhang, Q.,Stout, C.D.,Halpert, J.R.; Structures of cytochrome P450 2B4 complexed with the antiplatelet drugs ticlopidine and clopidogrel.; Biochemistry, 49:8709-8720, 2010; PubMed: 20815363; DOI: 10.1021/bi100914z

実験手法

X-RAY DIFFRACTION (3.1 Å)