3MDY
Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
Summary for 3MDY
Entry DOI | 10.2210/pdb3mdy/pdb |
Descriptor | Bone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, ... (4 entities in total) |
Functional Keywords | complex (isomerase-protein kinase), receptor serine/threonine kinase, structural genomics consortium, sgc, atp-binding, disease mutation, kinase, transferase, rotamase, transferase-isomerase complex, transferase/isomerase |
Biological source | Homo sapiens (human) More |
Cellular location | Membrane; Single-pass type I membrane protein: O00238 Cytoplasm: P62942 |
Total number of polymer chains | 4 |
Total formula weight | 101552.68 |
Authors | Chaikuad, A.,Sanvitale, C.,Mahajan, P.,Daga, N.,Cooper, C.,Krojer, T.,Alfano, I.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) (deposition date: 2010-03-31, release date: 2010-05-19, Last modification date: 2023-11-01) |
Primary citation | Chaikuad, A.,Sanvitale, C.,Mahajan, P.,Daga, N.,Cooper, C.,Krojer, T.,Alfano, I.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC) Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189 To be Published, |
Experimental method | X-RAY DIFFRACTION (2.05 Å) |
Structure validation
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