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3MDY

Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189

Summary for 3MDY
Entry DOI10.2210/pdb3mdy/pdb
DescriptorBone morphogenetic protein receptor type-1B, Peptidyl-prolyl cis-trans isomerase FKBP1A, 4-[6-(4-piperazin-1-ylphenyl)pyrazolo[1,5-a]pyrimidin-3-yl]quinoline, ... (4 entities in total)
Functional Keywordscomplex (isomerase-protein kinase), receptor serine/threonine kinase, structural genomics consortium, sgc, atp-binding, disease mutation, kinase, transferase, rotamase, transferase-isomerase complex, transferase/isomerase
Biological sourceHomo sapiens (human)
More
Cellular locationMembrane; Single-pass type I membrane protein: O00238
Cytoplasm: P62942
Total number of polymer chains4
Total formula weight101552.68
Authors
Primary citationChaikuad, A.,Sanvitale, C.,Mahajan, P.,Daga, N.,Cooper, C.,Krojer, T.,Alfano, I.,Knapp, S.,von Delft, F.,Weigelt, J.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Bullock, A.,Structural Genomics Consortium (SGC)
Crystal structure of the cytoplasmic domain of the bone morphogenetic protein receptor type-1B (BMPR1B) in complex with FKBP12 and LDN-193189
To be Published,
Experimental method
X-RAY DIFFRACTION (2.05 Å)
Structure validation

227561

数据于2024-11-20公开中

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