3MB4

Crystal Structure of the fifth Bromodomain of Human Poly-bromodomain containing protein 1 (PB1) with NMP

Summary for 3MB4

Entry DOI	10.2210/pdb3mb4/pdb
Related	3MB3
Descriptor	Protein polybromo-1, 1,2-ETHANEDIOL, 1-methylpyrrolidin-2-one, ... (5 entities in total)
Functional Keywords	pb1, polybromo 1 isoform 1, baf180, polybromo-1d, pbrm1, brg1-associated factor 180, structural genomics consortium, sgc, bromodomain, chromatin regulator, dna-binding, nucleus, phosphoprotein, transcription, transcription regulation
Biological source	Homo sapiens (human)
Cellular location	Nucleus: Q86U86
Total number of polymer chains	2
Total formula weight	29946.41
Authors	Filippakopoulos, P.,Picaud, S.,Keates, T.,Ugochukwu, E.,von Delft, F.,Arrowsmith, C.H.,Edwards, A.M.,Weigelt, J.,Bountra, C.,Knapp, S.,Structural Genomics Consortium (SGC) (deposition date: 2010-03-25, release date: 2010-04-14, Last modification date: 2023-09-06)
Primary citation	Filippakopoulos, P.,Picaud, S.,Mangos, M.,Keates, T.,Lambert, J.P.,Barsyte-Lovejoy, D.,Felletar, I.,Volkmer, R.,Muller, S.,Pawson, T.,Gingras, A.C.,Arrowsmith, C.H.,Knapp, S. Histone recognition and large-scale structural analysis of the human bromodomain family. Cell(Cambridge,Mass.), 149:214-231, 2012 Cited by PubMed: 22464331 DOI: 10.1016/j.cell.2012.02.013 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.66 Å)

Structure validation