3MAP

Crystal structure of homodimeric R132H mutant of human cytosolic NADP(+)-dependent isocitrate dehydrogenase in complex with NADP and isocitrate

3MAP の概要

• エントリーDOI: 10.2210/pdb3map/pdb
• 関連するPDBエントリー: 3MAR 3MAS
• 分子名称: Isocitrate dehydrogenase [NADP] cytoplasmic, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, ISOCITRIC ACID (3 entities in total)
• 機能のキーワード: isocitrate dehydrogenase, nicotinamide adenine dinucleotide phosphate, rossmann fold, oxidoreductase
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm : O75874
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 97415.69

構造登録者

Yang, B.,Peng, Y.,Ding, J. (登録日: 2010-03-24, 公開日: 2010-11-10, 最終更新日: 2023-11-01)

• 主引用文献: Yang, B.,Zhong, C.,Peng, Y.,Lai, Z.,Ding, J.; Molecular mechanisms of "off-on switch" of activities of human IDH1 by tumor-associated mutation R132H.; Cell Res., 20:1188-1200, 2010; PubMed: 20975740; DOI: 10.1038/cr.2010.145

実験手法

X-RAY DIFFRACTION (2.8 Å)