3M64

Human aldose reductase mutant T113V complexed with IDD393

Summary for 3M64

• Entry DOI: 10.2210/pdb3m64/pdb
• Related: 2IKJ 3LZ5 3M0I 3M4H
• Descriptor: Aldose reductase, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, (5-CHLORO-2-{[(3-NITROBENZYL)AMINO]CARBONYL}PHENOXY)ACETIC ACID, ... (4 entities in total)
• Functional Keywords: t113v mutant, tim-barrel, nadp, phosphoprotein, oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• Biological source: Homo sapiens (human)
• Cellular location: Cytoplasm: P15121
• Total number of polymer chains: 1
• Total formula weight: 37004.51

Authors

Koch, C.,Heine, A.,Klebe, G. (deposition date: 2010-03-15, release date: 2011-03-09, Last modification date: 2024-03-20)

• Primary citation: Koch, C.,Heine, A.,Klebe, G.; Ligand-induced fit affects binding modes and provokes changes in crystal packing of aldose reductase; Biochim.Biophys.Acta, 1810:879-887, 2011; PubMed: 21684320; DOI: 10.1016/j.bbagen.2011.06.001

Experimental method

X-RAY DIFFRACTION (1.3 Å)