3M37
Factor XA in complex with the inhibitor 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide (DPC602)
Summary for 3M37
Entry DOI | 10.2210/pdb3m37/pdb |
Related | 3M35 3M36 |
Descriptor | Coagulation factor X, 1-[2-(aminomethyl)phenyl]-N-(3-fluoro-2'-sulfamoylbiphenyl-4-yl)-3-(trifluoromethyl)-1H-pyrazole-5-carboxamide, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | glycoprotein, hydrolase, serine protease, plasma, blood coagulation factor, protein inhibitor complex, calcium- binding, blood coagulation, cleavage on pair of basic residues, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, polymorphism, protease, secreted, zymogen |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00742 P00742 |
Total number of polymer chains | 2 |
Total formula weight | 32609.91 |
Authors | Alexander, R.S. (deposition date: 2010-03-08, release date: 2010-04-21, Last modification date: 2011-07-13) |
Primary citation | Pruitt, J.R.,Pinto, D.J.P.,Galemmo, R.A.Jr.,Alexander, R.S.,Rossi, K.A.,Wells, B.L.,Drummond, S.,Bostrom, L.L.,Burdick, D.,Bruckner, R.,Chen, H.,Smallwood, A.,Wong, P.C.,Wright, M.R.,Bai, S.,Luettgen, J.M.,Knabb, R.M.,Lam, P.Y.S.,Wexler, R.R. Discovery of 1-(2-Aminomethylphenyl)-3-trifluoromethyl-N-[3-fluoro-2'-(aminosulfonyl)[1,1'-biphenyl)]-1H-pyrazole-5-carboxyamide (DPC602), a Potent, Selective, and Orally Bioavailable Factor Xa Inhibitor. J.Med.Chem., 46:5298-5315, 2003 Cited by PubMed: 14640539PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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