3M1N

Crystal structure of Human Sonic Hedgehog N-terminal domain

3M1N の概要

• エントリーDOI: 10.2210/pdb3m1n/pdb
• 分子名称: Sonic hedgehog protein, ZINC ION, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hedgehog proteins, signaling, zinc ions, sulfate ions, autocatalytic cleavage, cell membrane, developmental protein, glycoprotein, holoprosencephaly, hydrolase, lipoprotein, membrane, microphthalmia, palmitate, protease, secreted, signaling protein
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Sonic hedgehog protein C-product: Secreted, extracellular space (By similarity). Sonic hedgehog protein N-product: Cell membrane; Lipid-anchor (By similarity): Q15465
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 40429.81

構造登録者

Boriack-Sjodin, P.A.,Pepinsky, R.B.,Garber, E.A.,Silvian, L.F. (登録日: 2010-03-05, 公開日: 2010-03-16, 最終更新日: 2023-09-06)

• 主引用文献: Pepinsky, R.B.,Rayhorn, P.,Day, E.S.,Dergay, A.,Williams, K.P.,Galdes, A.,Taylor, F.R.,Boriack-Sjodin, P.A.,Garber, E.A.; Mapping sonic hedgehog-receptor interactions by steric interference.; J.Biol.Chem., 275:10995-11001, 2000; PubMed: 10753901; DOI: 10.1074/jbc.275.15.10995

実験手法

X-RAY DIFFRACTION (1.85 Å)