3LZF

Crystal Structure of Fab 2D1 in Complex with the 1918 Influenza Virus Hemagglutinin

3LZF の概要

• エントリーDOI: 10.2210/pdb3lzf/pdb
• 関連するPDBエントリー: 3LZG
• 分子名称: Hemagglutinin, HA1 Subunit, Hemagglutinin, HA2 Subunit, 2D1 Fab, Heavy Chain, ... (7 entities in total)
• 機能のキーワード: hemagglutinin, fab, neutralizing antibodies, antibody, pandemic flu, swine flu, envelope protein, fusion protein, glycoprotein, antigen, virion, viral protein-immune system complex, viral protein/immune system
• 由来する生物種: Influenza A virus (Influenza A virus); 詳細
• 細胞内の位置: Virion membrane; Single-pass type I membrane protein (Potential): Q9WFX3 Q9WFX3
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 106177.88

構造登録者

Ekiert, D.C.,Wilson, I.A. (登録日: 2010-03-01, 公開日: 2010-04-07, 最終更新日: 2024-11-20)

主引用文献

Xu, R.,Ekiert, D.C.,Krause, J.C.,Hai, R.,Crowe, J.E.,Wilson, I.A.
Structural basis of preexisting immunity to the 2009 H1N1 pandemic influenza virus.
Science, 328:357-360, 2010

PubMed Abstract: The 2009 H1N1 swine flu is the first influenza pandemic in decades. The crystal structure of the hemagglutinin from the A/California/04/2009 H1N1 virus shows that its antigenic structure, particularly within the Sa antigenic site, is extremely similar to those of human H1N1 viruses circulating early in the 20th century. The cocrystal structure of the 1918 hemagglutinin with 2D1, an antibody from a survivor of the 1918 Spanish flu that neutralizes both 1918 and 2009 H1N1 viruses, reveals an epitope that is conserved in both pandemic viruses. Thus, antigenic similarity between the 2009 and 1918-like viruses provides an explanation for the age-related immunity to the current influenza pandemic.

PubMed: 20339031
DOI: 10.1126/science.1186430

実験手法

X-RAY DIFFRACTION (2.8 Å)