3LZ6

Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423

Summary for 3LZ6

Entry DOI	10.2210/pdb3lz6/pdb
Descriptor	Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-adamantan-2-yl-1-ethyl-D-prolinamide, ... (4 entities in total)
Functional Keywords	oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
Biological source	Cavia porcellus (guinea pig)
Cellular location	Endoplasmic reticulum membrane; Single-pass type II membrane protein: Q6QLL4
Total number of polymer chains	4
Total formula weight	119229.22
Authors	Pauly, T.A. (deposition date: 2010-03-01, release date: 2011-05-04, Last modification date: 2024-02-21)
Primary citation	Cheng, H.,Hoffman, J.,Le, P.,Nair, S.K.,Cripps, S.,Matthews, J.,Smith, C.,Yang, M.,Kupchinsky, S.,Dress, K.,Edwards, M.,Cole, B.,Walters, E.,Loh, C.,Ermolieff, J.,Fanjul, A.,Bhat, G.B.,Herrera, J.,Pauly, T.,Hosea, N.,Paderes, G.,Rejto, P. The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors. Bioorg.Med.Chem.Lett., 20:2897-2902, 2010 Cited by PubMed: 20363126 DOI: 10.1016/j.bmcl.2010.03.032 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.84 Å)

Structure validation