3LZ6

Guinea Pig 11beta hydroxysteroid dehydrogenase with PF-877423

3LZ6 の概要

• エントリーDOI: 10.2210/pdb3lz6/pdb
• 分子名称: Corticosteroid 11-beta-dehydrogenase isozyme 1, NADP NICOTINAMIDE-ADENINE-DINUCLEOTIDE PHOSPHATE, N-adamantan-2-yl-1-ethyl-D-prolinamide, ... (4 entities in total)
• 機能のキーワード: oxidoreductase-oxidoreductase inhibitor complex, oxidoreductase/oxidoreductase inhibitor
• 由来する生物種: Cavia porcellus (guinea pig)
• 細胞内の位置: Endoplasmic reticulum membrane; Single-pass type II membrane protein: Q6QLL4
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 119229.22

構造登録者

Pauly, T.A. (登録日: 2010-03-01, 公開日: 2011-05-04, 最終更新日: 2024-02-21)

• 主引用文献: Cheng, H.,Hoffman, J.,Le, P.,Nair, S.K.,Cripps, S.,Matthews, J.,Smith, C.,Yang, M.,Kupchinsky, S.,Dress, K.,Edwards, M.,Cole, B.,Walters, E.,Loh, C.,Ermolieff, J.,Fanjul, A.,Bhat, G.B.,Herrera, J.,Pauly, T.,Hosea, N.,Paderes, G.,Rejto, P.; The development and SAR of pyrrolidine carboxamide 11beta-HSD1 inhibitors.; Bioorg.Med.Chem.Lett., 20:2897-2902, 2010; PubMed: 20363126; DOI: 10.1016/j.bmcl.2010.03.032

実験手法

X-RAY DIFFRACTION (1.84 Å)