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3LXP

Structural and Thermodynamic Characterization of the TYK2 and JAK3 Kinase Domains in Complex with CP-690550 and CMP-6

Summary for 3LXP
Entry DOI10.2210/pdb3lxp/pdb
Related1YVJ 2B7A 3EYG 3EYH 3FUP 3LXK 3LXL 3LXN
DescriptorNon-receptor tyrosine-protein kinase TYK2, 2-TERT-BUTYL-9-FLUORO-3,6-DIHYDRO-7H-BENZ[H]-IMIDAZ[4,5-F]ISOQUINOLINE-7-ONE (3 entities in total)
Functional Keywordstyk2, jak3, inflammation, cancer, pan inhibitor, atp-binding, kinase, nucleotide-binding, phosphoprotein, sh2 domain, transferase, tyrosine-protein kinase
Biological sourceHomo sapiens (human)
Total number of polymer chains1
Total formula weight36843.91
Authors
Chrencik, J.E.,Benson, T.E. (deposition date: 2010-02-25, release date: 2010-06-02, Last modification date: 2023-11-22)
Primary citationChrencik, J.E.,Patny, A.,Leung, I.K.,Korniski, B.,Emmons, T.L.,Hall, T.,Weinberg, R.A.,Gormley, J.A.,Williams, J.M.,Day, J.E.,Hirsch, J.L.,Kiefer, J.R.,Leone, J.W.,Fischer, H.D.,Sommers, C.D.,Huang, H.C.,Jacobsen, E.J.,Tenbrink, R.E.,Tomasselli, A.G.,Benson, T.E.
Structural and thermodynamic characterization of the TYK2 and JAK3 kinase domains in complex with CP-690550 and CMP-6.
J.Mol.Biol., 400:413-433, 2010
Cited by
PubMed: 20478313
DOI: 10.1016/j.jmb.2010.05.020
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (1.65 Å)
Structure validation

217705

數據於2024-03-27公開中

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