3LXB

Interconversion of Human Lysosomal Enzyme Specificities

3LXB の概要

• エントリーDOI: 10.2210/pdb3lxb/pdb
• 関連するPDBエントリー: 1R46 3HG2 3LX9 3LXA 3LXC
• 分子名称: Alpha-galactosidase A, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (6 entities in total)
• 機能のキーワード: glycoprotein, carbohydrate-binding protein, glycosidase, lysosomal enzyme, (beta/alpha)8 barrel, enzyme interconversion, disease mutation, disulfide bond, hydrolase, lysosome
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 95416.55

構造登録者

Tomasic, I.B.,Metcalf, M.C.,Guce, A.I.,Clark, N.E.,Garman, S.C. (登録日: 2010-02-25, 公開日: 2010-05-05, 最終更新日: 2023-09-06)

• 主引用文献: Tomasic, I.B.,Metcalf, M.C.,Guce, A.I.,Clark, N.E.,Garman, S.C.; Interconversion of the specificities of human lysosomal enzymes associated with Fabry and Schindler diseases.; J.Biol.Chem., 285:21560-21566, 2010; PubMed: 20444686; DOI: 10.1074/jbc.M110.118588

実験手法

X-RAY DIFFRACTION (2.85 Å)