3LXB

Interconversion of Human Lysosomal Enzyme Specificities

Functional Information from GO Data

Chain	GOid	namespace	contents
A	0003824	molecular_function	catalytic activity
A	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
A	0004557	molecular_function	alpha-galactosidase activity
A	0005102	molecular_function	signaling receptor binding
A	0005515	molecular_function	protein binding
A	0005576	cellular_component	extracellular region
A	0005737	cellular_component	cytoplasm
A	0005764	cellular_component	lysosome
A	0005794	cellular_component	Golgi apparatus
A	0005975	biological_process	carbohydrate metabolic process
A	0006629	biological_process	lipid metabolic process
A	0009311	biological_process	oligosaccharide metabolic process
A	0016020	cellular_component	membrane
A	0016139	biological_process	glycoside catabolic process
A	0016787	molecular_function	hydrolase activity
A	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
A	0035578	cellular_component	azurophil granule lumen
A	0042803	molecular_function	protein homodimerization activity
A	0043202	cellular_component	lysosomal lumen
A	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
A	0046477	biological_process	glycosylceramide catabolic process
A	0046479	biological_process	glycosphingolipid catabolic process
A	0051001	biological_process	negative regulation of nitric-oxide synthase activity
A	0070062	cellular_component	extracellular exosome
B	0003824	molecular_function	catalytic activity
B	0004553	molecular_function	hydrolase activity, hydrolyzing O-glycosyl compounds
B	0004557	molecular_function	alpha-galactosidase activity
B	0005102	molecular_function	signaling receptor binding
B	0005515	molecular_function	protein binding
B	0005576	cellular_component	extracellular region
B	0005737	cellular_component	cytoplasm
B	0005764	cellular_component	lysosome
B	0005794	cellular_component	Golgi apparatus
B	0005975	biological_process	carbohydrate metabolic process
B	0006629	biological_process	lipid metabolic process
B	0009311	biological_process	oligosaccharide metabolic process
B	0016020	cellular_component	membrane
B	0016139	biological_process	glycoside catabolic process
B	0016787	molecular_function	hydrolase activity
B	0016798	molecular_function	hydrolase activity, acting on glycosyl bonds
B	0035578	cellular_component	azurophil granule lumen
B	0042803	molecular_function	protein homodimerization activity
B	0043202	cellular_component	lysosomal lumen
B	0045019	biological_process	negative regulation of nitric oxide biosynthetic process
B	0046477	biological_process	glycosylceramide catabolic process
B	0046479	biological_process	glycosphingolipid catabolic process
B	0051001	biological_process	negative regulation of nitric-oxide synthase activity
B	0070062	cellular_component	extracellular exosome

Functional Information from PROSITE/UniProt

site_id	PS00512
Number of Residues	17
Details	ALPHA_GALACTOSIDASE Alpha-galactosidase signature. GYeyLcIDDc.Wmapq...RD

Chain	Residue	Details
A	GLY85-ASP101

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Functional Information from SwissProt/UniProt

site_id	SWS_FT_FI1
Number of Residues	2
Details	Active site: {"description":"Nucleophile","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI2
Number of Residues	2
Details	Active site: {"description":"Proton donor","evidences":[{"evidenceCode":"ECO:0000250"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI3
Number of Residues	8
Details	Binding site: {}

Chain

Residue

Details

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site_id	SWS_FT_FI4
Number of Residues	4
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15003450","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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site_id	SWS_FT_FI5
Number of Residues	2
Details	Glycosylation: {"description":"N-linked (GlcNAc...) asparagine","evidences":[{"source":"PubMed","id":"15003450","evidenceCode":"ECO:0000269"},{"source":"PubMed","id":"19159218","evidenceCode":"ECO:0000269"}]}

Chain

Residue

Details

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