3LWE

The crystal structure of MPP8

Summary for 3LWE

• Entry DOI: 10.2210/pdb3lwe/pdb
• Related: 3R93
• Descriptor: M-phase phosphoprotein 8 (2 entities in total)
• Functional Keywords: mpp8, structural genomics, structural genomics consortium, sgc, ank repeat, nucleus, phosphoprotein, cell cycle
• Biological source: Homo sapiens (human)
• Cellular location: Nucleus : Q99549
• Total number of polymer chains: 2
• Total formula weight: 14688.70

Authors

Li, Z.,Li, Z.,Ruan, J.,Xu, C.,Tong, Y.,Pan, P.W.,Tempel, W.,Crombet, L.,Min, J.,Zang, J.,Structural Genomics Consortium (SGC) (deposition date: 2010-02-23, release date: 2010-03-02, Last modification date: 2023-09-06)

Primary citation

Li, J.,Li, Z.,Ruan, J.,Xu, C.,Tong, Y.,Pan, P.W.,Tempel, W.,Crombet, L.,Min, J.,Zang, J.
Structural basis for specific binding of human MPP8 chromodomain to histone H3 methylated at lysine 9.
Plos One, 6:e25104-e25104, 2011

PubMed Abstract: M-phase phosphoprotein 8 (MPP8) was initially identified to be a component of the RanBPM-containing large protein complex, and has recently been shown to bind to methylated H3K9 both in vivo and in vitro. MPP8 binding to methylated H3K9 is suggested to recruit the H3K9 methyltransferases GLP and ESET, and DNA methyltransferase 3A to the promoter of the E-cadherin gene, mediating the E-cadherin gene silencing and promote tumor cell motility and invasion. MPP8 contains a chromodomain in its N-terminus, which is used to bind the methylated H3K9.

PubMed: 22022377
DOI: 10.1371/journal.pone.0025104

Experimental method

X-RAY DIFFRACTION (2.05 Å)