3LV5

Crystal structure of the mutant I199E of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP

3LV5 の概要

• エントリーDOI: 10.2210/pdb3lv5/pdb
• 関連するPDBエントリー: 3LHW 3LTP 3LTS 3LTY 3LV6
• 分子名称: Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE (3 entities in total)
• 機能のキーワード: mutant i199e, decarboxylase, lyase, pyrimidine biosynthesis
• 由来する生物種: Methanothermobacter thermautotrophicus
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 50481.67

構造登録者

Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (登録日: 2010-02-19, 公開日: 2010-06-16, 最終更新日: 2023-09-06)

• 主引用文献: Wood, B.M.,Amyes, T.L.,Fedorov, A.A.,Fedorov, E.V.,Shabila, A.,Almo, S.C.,Richard, J.P.,Gerlt, J.A.; Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation.; Biochemistry, 49:3514-3516, 2010; PubMed: 20369850; DOI: 10.1021/bi100443a

実験手法

X-RAY DIFFRACTION (1.444 Å)