3LTY
Crystal structure of the mutant V182A,I218A of orotidine 5'-monophosphate decarboxylase from Methanobacterium thermoautotrophicum complexed with inhibitor BMP
Summary for 3LTY
Entry DOI | 10.2210/pdb3lty/pdb |
Related | 3LHW 3LTP 3LTS 3LV5 3LV6 |
Descriptor | Orotidine 5'-phosphate decarboxylase, 6-HYDROXYURIDINE-5'-PHOSPHATE (3 entities in total) |
Functional Keywords | mutant v182a.i218a, inhibitor bmp, decarboxylase, lyase, pyrimidine biosynthesis |
Biological source | Methanothermobacter thermautotrophicus |
Total number of polymer chains | 2 |
Total formula weight | 50309.49 |
Authors | Fedorov, A.A.,Fedorov, E.V.,Wood, B.M.,Gerlt, J.A.,Almo, S.C. (deposition date: 2010-02-16, release date: 2010-06-16, Last modification date: 2023-09-06) |
Primary citation | Wood, B.M.,Amyes, T.L.,Fedorov, A.A.,Fedorov, E.V.,Shabila, A.,Almo, S.C.,Richard, J.P.,Gerlt, J.A. Conformational changes in orotidine 5'-monophosphate decarboxylase: "remote" residues that stabilize the active conformation. Biochemistry, 49:3514-3516, 2010 Cited by PubMed: 20369850DOI: 10.1021/bi100443a PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.5 Å) |
Structure validation
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