3LTH
E. cloacae MurA dead-end complex with UNAG and fosfomycin
Summary for 3LTH
Entry DOI | 10.2210/pdb3lth/pdb |
Related | 3KQA 3KR6 |
Descriptor | UDP-N-acetylglucosamine 1-carboxyvinyltransferase, [(1R)-1-hydroxypropyl]phosphonic acid, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... (4 entities in total) |
Functional Keywords | open enzyme state, inside-out alpha/beta barrel, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-antibiotic complex, transferase/antibiotic |
Biological source | Enterobacter cloacae |
Cellular location | Cytoplasm (Probable): P33038 |
Total number of polymer chains | 1 |
Total formula weight | 45576.83 |
Authors | Schonbrunn, E. (deposition date: 2010-02-15, release date: 2010-05-05, Last modification date: 2023-09-06) |
Primary citation | Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E. The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) . Biochemistry, 49:4276-4282, 2010 Cited by PubMed: 20392080DOI: 10.1021/bi100365b PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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