3LTH

E. cloacae MurA dead-end complex with UNAG and fosfomycin

Summary for 3LTH

• Entry DOI: 10.2210/pdb3lth/pdb
• Related: 3KQA 3KR6
• Descriptor: UDP-N-acetylglucosamine 1-carboxyvinyltransferase, [(1R)-1-hydroxypropyl]phosphonic acid, URIDINE-DIPHOSPHATE-N-ACETYLGLUCOSAMINE, ... (4 entities in total)
• Functional Keywords: open enzyme state, inside-out alpha/beta barrel, cell wall biogenesis/degradation, peptidoglycan synthesis, transferase, transferase-antibiotic complex, transferase/antibiotic
• Biological source: Enterobacter cloacae
• Cellular location: Cytoplasm (Probable): P33038
• Total number of polymer chains: 1
• Total formula weight: 45576.83

Authors

Schonbrunn, E. (deposition date: 2010-02-15, release date: 2010-05-05, Last modification date: 2023-09-06)

• Primary citation: Han, H.,Yang, Y.,Olesen, S.H.,Becker, A.,Betzi, S.,Schonbrunn, E.; The fungal product terreic acid is a covalent inhibitor of the bacterial cell wall biosynthetic enzyme UDP-N-acetylglucosamine 1-carboxyvinyltransferase (MurA) .; Biochemistry, 49:4276-4282, 2010; PubMed: 20392080; DOI: 10.1021/bi100365b

Experimental method

X-RAY DIFFRACTION (1.75 Å)