3LS8

Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol

3LS8 の概要

• エントリーDOI: 10.2210/pdb3ls8/pdb
• 関連するPDBエントリー: 3IHY
• 分子名称: Phosphatidylinositol 3-kinase catalytic subunit type 3, 3-(4-morpholin-4-ylthieno[3,2-d]pyrimidin-2-yl)phenol, CHLORIDE ION, ... (5 entities in total)
• 機能のキーワード: alpha/beta protein, pik3c3, phosphatidylinositol 3-kinase catalytic subunit type 3, compound 15e, structural genomics, sgc stockholm, structural genomics consortium, sgc, atp-binding, kinase, nucleotide-binding, phosphoprotein, transferase, inhibitor, phosphatidylinositol
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Midbody: Q8NEB9
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 141097.06

構造登録者

Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Kraulis, P.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,Van den Berg, S.,Wahlberg, E.,Weigelt, J.,Wisniewska, M.,Nordlund, P.,Structural Genomics Consortium (SGC) (登録日: 2010-02-12, 公開日: 2010-03-23, 最終更新日: 2023-09-06)

• 主引用文献: Tresaugues, L.,Welin, M.,Arrowsmith, C.H.,Berglund, H.,Bountra, C.,Collins, R.,Edwards, A.M.,Flodin, S.,Flores, A.,Graslund, S.,Hammarstrom, M.,Johansson, I.,Karlberg, T.,Kotenyova, T.,Kraulis, P.,Moche, M.,Nyman, T.,Persson, C.,Schuler, H.,Schutz, P.,Siponen, M.I.,Thorsell, A.G.,Van den Berg, S.,Wahlberg, E.,Weigelt, J.,Wisniewska, M.,Nordlund, P.; Crystal structure of human PIK3C3 in complex with 3-[4-(4-Morpholinyl)thieno[3,2-d]pyrimidin-2-yl]-phenol; To be Published,

実験手法

X-RAY DIFFRACTION (2.25 Å)