3LQ3

Crystal structure of human choline kinase beta in complex with phosphorylated hemicholinium-3 and adenosine nucleotide

3LQ3 の概要

• エントリーDOI: 10.2210/pdb3lq3/pdb
• 分子名称: Choline/ethanolamine kinase, (2S)-2-[4'-({dimethyl[2-(phosphonooxy)ethyl]ammonio}acetyl)biphenyl-4-yl]-2-hydroxy-4,4-dimethylmorpholin-4-ium, MAGNESIUM ION, ... (8 entities in total)
• 機能のキーワード: non-protein kinase, choline kinase, structural genomics consortium, sgc, hemicholinium-3, phosphorylation, atp-binding, kinase, nucleotide-binding, phospholipid biosynthesis, phosphoprotein, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 47654.56

構造登録者

Hong, B.S.,Tempel, W.,Rabeh, W.M.,MacKenzie, F.,Arrowsmith, C.H.,Edwards, A.M.,Bountra, C.,Weigelt, J.,Bochkarev, A.,Park, H.W.,Structural Genomics Consortium (SGC) (登録日: 2010-02-08, 公開日: 2010-05-05, 最終更新日: 2023-09-06)

• 主引用文献: Hong, B.S.,Allali-Hassani, A.,Tempel, W.,Finerty, P.J.,Mackenzie, F.,Dimov, S.,Vedadi, M.,Park, H.W.; Crystal structures of human choline kinase isoforms in complex with hemicholinium-3: single amino acid near the active site influences inhibitor sensitivity.; J.Biol.Chem., 285:16330-16340, 2010; PubMed: 20299452; DOI: 10.1074/jbc.M109.039024

実験手法

X-RAY DIFFRACTION (1.42 Å)