3LPU
HIV integrase
Summary for 3LPU
Entry DOI | 10.2210/pdb3lpu/pdb |
Related | 1HYV 3LPT |
Descriptor | Integrase, (2S)-2-(6-chloro-2-methyl-4-phenylquinolin-3-yl)pentanoic acid, 2-[3-[3-(2-hydroxyethoxy)propoxy]propoxy]ethanol, ... (7 entities in total) |
Functional Keywords | hiv, integrase, ledgf/p75 small molecule, inhibitor, endonuclease, hydrolase, nuclease, transferase, viral protein |
Biological source | Human immunodeficiency virus 1 |
Total number of polymer chains | 1 |
Total formula weight | 19551.35 |
Authors | Nicolet, S.,Christ, F.,Voet, A.,Marchand, A.,Strelkov, S.V.,de Maeyer, M.,Chaltin, P.,Debyzer, Z. (deposition date: 2010-02-06, release date: 2010-05-12, Last modification date: 2021-11-10) |
Primary citation | Christ, F.,Voet, A.,Marchand, A.,Nicolet, S.,Desimmie, B.A.,Marchand, D.,Bardiot, D.,Van der Veken, N.J.,Van Remoortel, B.,Strelkov, S.V.,De Maeyer, M.,Chaltin, P.,Debyser, Z. Rational design of small-molecule inhibitors of the LEDGF/p75-integrase interaction and HIV replication. Nat.Chem.Biol., 6:442-448, 2010 Cited by PubMed: 20473303DOI: 10.1038/nchembio.370 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.95 Å) |
Structure validation
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