3LPP

Crystal complex of N-terminal sucrase-isomaltase with kotalanol

3LPP の概要

• エントリーDOI: 10.2210/pdb3lpp/pdb
• 関連するPDBエントリー: 3LPO
• 分子名称: Sucrase-isomaltase, alpha-D-mannopyranose-(1-3)-beta-D-mannopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, 2-acetamido-2-deoxy-beta-D-glucopyranose-(1-4)-2-acetamido-2-deoxy-beta-D-glucopyranose, ... (10 entities in total)
• 機能のキーワード: glycoside hydrolase family 31, isomaltase, alpha-glucosidase, cell membrane, disease mutation, disulfide bond, glycoprotein, glycosidase, hydrolase, membrane, multifunctional enzyme, polymorphism, signal-anchor, sulfation, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Apical cell membrane; Single-pass type II membrane protein: P14410
• タンパク質・核酸の鎖数: 4
• 化学式量合計: 417299.67

構造登録者

Sim, L.,Rose, D.R. (登録日: 2010-02-05, 公開日: 2010-03-31, 最終更新日: 2020-07-29)

• 主引用文献: Sim, L.,Willemsma, C.,Mohan, S.,Naim, H.Y.,Pinto, B.M.,Rose, D.R.; Structural basis for substrate selectivity in human maltase-glucoamylase and sucrase-isomaltase N-terminal domains.; J.Biol.Chem., 285:17763-17770, 2010; PubMed: 20356844; DOI: 10.1074/jbc.M109.078980

実験手法

X-RAY DIFFRACTION (2.15 Å)