3LPG

Structure of E. coli beta-Glucuronidase bound with a novel, potent inhibitor 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-((6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl)urea

3LPG の概要

• エントリーDOI: 10.2210/pdb3lpg/pdb
• 関連するPDBエントリー: 3K46 3K4A 3K4D 3LPF
• 分子名称: Beta-glucuronidase, 3-(2-fluorophenyl)-1-(2-hydroxyethyl)-1-[(6-methyl-2-oxo-1,2-dihydroquinolin-3-yl)methyl]urea (3 entities in total)
• 機能のキーワード: alpha/beta barrel, sugar-binding domain, beta-sandwich domain, glycosyl hydrolase, glycosidase, hydrolase, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Escherichia coli
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 139451.98

構造登録者

Wallace, B.D.,Redinbo, M.R. (登録日: 2010-02-05, 公開日: 2010-11-17, 最終更新日: 2023-11-22)

• 主引用文献: Wallace, B.D.,Wang, H.,Lane, K.T.,Scott, J.E.,Orans, J.,Koo, J.S.,Venkatesh, M.,Jobin, C.,Yeh, L.A.,Mani, S.,Redinbo, M.R.; Alleviating cancer drug toxicity by inhibiting a bacterial enzyme.; Science, 330:831-835, 2010; PubMed: 21051639; DOI: 10.1126/science.1191175

実験手法

X-RAY DIFFRACTION (2.425 Å)