3LP7

Crystal structure of Human Arginase I in complex with inhibitor N(omega)-hydroxy-L-arginine (NOHA), 2.04A Resolution

3LP7 の概要

• エントリーDOI: 10.2210/pdb3lp7/pdb
• 関連するPDBエントリー: 2ZAV 3LP4 5CEV
• 分子名称: Arginase-1, MANGANESE (II) ION, N-OMEGA-HYDROXY-L-ARGININE, ... (4 entities in total)
• 機能のキーワード: noha inhibition, manganese cluster, alternative splicing, arginine metabolism, cytoplasm, disease mutation, hydrolase, manganese, metal-binding, phosphoprotein, polymorphism, urea cycle
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Cytoplasm: P05089
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 70159.91

構造登録者

Di Costanzo, L.,Christianson, D.W. (登録日: 2010-02-04, 公開日: 2010-02-23, 最終更新日: 2023-09-06)

• 主引用文献: Di Costanzo, L.,Ilies, M.,Thorn, K.J.,Christianson, D.W.; Inhibition of human arginase I by substrate and product analogues.; Arch.Biochem.Biophys., 496:101-108, 2010; PubMed: 20153713; DOI: 10.1016/j.abb.2010.02.004

実験手法

X-RAY DIFFRACTION (2.04 Å)