3LP1
HIV-1 reverse transcriptase with inhibitor
Summary for 3LP1
Entry DOI | 10.2210/pdb3lp1/pdb |
Related | 3LP0 3LP2 3LP3 |
Descriptor | Reverse transcriptase/ribonuclease H, p51 RT, 3-cyclopentyl-1,4-dihydroxy-1,8-naphthyridin-2(1H)-one, ... (6 entities in total) |
Functional Keywords | reverse transcriptase, rnase h, hiv, aids, capsid maturation, dna integration, dna-directed dna polymerase, endonuclease, host cytoplasm, host membrane, host nucleus, host-virus interaction, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, transferase-hydrolase complex, transferase/hydrolase |
Biological source | Human immunodeficiency virus type 1 (HIV-1) More |
Cellular location | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
Total number of polymer chains | 2 |
Total formula weight | 117219.01 |
Authors | Yan, Y.,Munshi, S.K.,Prasad, G.S.,Su, H.P. (deposition date: 2010-02-04, release date: 2010-06-09, Last modification date: 2024-02-21) |
Primary citation | Su, H.P.,Yan, Y.,Prasad, G.S.,Smith, R.F.,Daniels, C.L.,Abeywickrema, P.D.,Reid, J.C.,Loughran, H.M.,Kornienko, M.,Sharma, S.,Grobler, J.A.,Xu, B.,Sardana, V.,Allison, T.J.,Williams, P.D.,Darke, P.L.,Hazuda, D.J.,Munshi, S. Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. J.Virol., 84:7625-7633, 2010 Cited by PubMed: 20484498DOI: 10.1128/JVI.00353-10 PDB entries with the same primary citation |
Experimental method |
Structure validation
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