3LP1
HIV-1 reverse transcriptase with inhibitor
3LP1 の概要
エントリーDOI | 10.2210/pdb3lp1/pdb |
関連するPDBエントリー | 3LP0 3LP2 3LP3 |
分子名称 | Reverse transcriptase/ribonuclease H, p51 RT, 3-cyclopentyl-1,4-dihydroxy-1,8-naphthyridin-2(1H)-one, ... (6 entities in total) |
機能のキーワード | reverse transcriptase, rnase h, hiv, aids, capsid maturation, dna integration, dna-directed dna polymerase, endonuclease, host cytoplasm, host membrane, host nucleus, host-virus interaction, hydrolase, magnesium, membrane, metal-binding, multifunctional enzyme, myristate, nuclease, nucleotidyltransferase, rna-binding, rna-directed dna polymerase, transferase, viral nucleoprotein, virion, transferase-hydrolase complex, transferase/hydrolase |
由来する生物種 | Human immunodeficiency virus type 1 (HIV-1) 詳細 |
細胞内の位置 | Gag-Pol polyprotein: Host cell membrane; Lipid-anchor . Matrix protein p17: Virion membrane; Lipid- anchor . Capsid protein p24: Virion . Nucleocapsid protein p7: Virion . Reverse transcriptase/ribonuclease H: Virion . Integrase: Virion : P04585 P04585 |
タンパク質・核酸の鎖数 | 2 |
化学式量合計 | 117219.01 |
構造登録者 | |
主引用文献 | Su, H.P.,Yan, Y.,Prasad, G.S.,Smith, R.F.,Daniels, C.L.,Abeywickrema, P.D.,Reid, J.C.,Loughran, H.M.,Kornienko, M.,Sharma, S.,Grobler, J.A.,Xu, B.,Sardana, V.,Allison, T.J.,Williams, P.D.,Darke, P.L.,Hazuda, D.J.,Munshi, S. Structural basis for the inhibition of RNase H activity of HIV-1 reverse transcriptase by RNase H active site-directed inhibitors. J.Virol., 84:7625-7633, 2010 Cited by PubMed: 20484498DOI: 10.1128/JVI.00353-10 主引用文献が同じPDBエントリー |
実験手法 | X-RAY DIFFRACTION (2.23 Å) |
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