3LLR

Crystal structure of the PWWP domain of Human DNA (cytosine-5-)-methyltransferase 3 alpha

3LLR の概要

• エントリーDOI: 10.2210/pdb3llr/pdb
• 分子名称: DNA (cytosine-5)-methyltransferase 3A, 2-[BIS-(2-HYDROXY-ETHYL)-AMINO]-2-HYDROXYMETHYL-PROPANE-1,3-DIOL, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: transferase, dna methyltransferase, methylysine binding, structural genomics consortium, sgc, alternative promoter usage, chromatin regulator, dna-binding, metal-binding, methyltransferase, nucleus, phosphoprotein, repressor, s-adenosyl-l-methionine, zinc-finger
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Nucleus : Q9Y6K1
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 87444.76

構造登録者

Qiu, W.,Dombrovski, L.,Ni, S.,Weigelt, J.,Boutra, C.,Arrowsmith, C.H.,Edwards, A.M.,Min, J.,Wu, H.,Structural Genomics Consortium (SGC) (登録日: 2010-01-29, 公開日: 2010-03-23, 最終更新日: 2023-09-06)

主引用文献

Wu, H.,Zeng, H.,Lam, R.,Tempel, W.,Amaya, M.F.,Xu, C.,Dombrovski, L.,Qiu, W.,Wang, Y.,Min, J.
Structural and histone binding ability characterizations of human PWWP domains.
Plos One, 6:e18919-e18919, 2011

PubMed Abstract: The PWWP domain was first identified as a structural motif of 100-130 amino acids in the WHSC1 protein and predicted to be a protein-protein interaction domain. It belongs to the Tudor domain 'Royal Family', which consists of Tudor, chromodomain, MBT and PWWP domains. While Tudor, chromodomain and MBT domains have long been known to bind methylated histones, PWWP was shown to exhibit histone binding ability only until recently.

PubMed: 21720545
DOI: 10.1371/journal.pone.0018919

実験手法

X-RAY DIFFRACTION (2.3 Å)