3QGZ

Re-investigated high resolution crystal structure of histidine triad nucleotide-binding protein 1 (HINT1) from rabbit complexed with adenosine

Replaces:  3LLJ

Summary for 3QGZ

• Entry DOI: 10.2210/pdb3qgz/pdb
• Related: 1RZY 3LLJ 3RHN 4RHN 5RHN 6RHN
• Descriptor: Histidine triad nucleotide-binding protein 1, ADENOSINE (3 entities in total)
• Functional Keywords: hint protein, hit family protein, hydrolase, adenosine 5'-monophosphoramidase
• Biological source: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• Cellular location: Cytoplasm: P80912
• Total number of polymer chains: 1
• Total formula weight: 13981.08

Authors

Dolot, R.M.,Ozga, M.,Krakowiak, A.,Nawrot, B.,Stec, W.J. (deposition date: 2011-01-25, release date: 2011-02-16, Last modification date: 2023-09-13)

Primary citation

Dolot, R.,Ozga, M.,Krakowiak, A.,Nawrot, B.
High-resolution X-ray crystal structure of rabbit histidine triad nucleotide-binding protein 1 (rHINT1) - adenosine complex at 1.10A resolution
Acta Crystallogr.,Sect.D, 67:601-607, 2011

PubMed Abstract: Histidine triad nucleotide-binding protein 1 (HINT1) represents the most ancient and widespread branch in the histidine-triad protein superfamily. HINT1 plays an important role in various biological processes and has been found in many species. Here, the first complete structure of the rabbit HINT1-adenosine complex is reported at 1.10 Å resolution, which is one of the highest resolutions obtained for a HINT1 structure. The final structure has an R(cryst) of 14.25% (R(free) = 16.77%) and the model exhibits good stereochemical qualities. A detailed analysis of the atomic resolution data allowed an update of the details of the protein structure in comparison to previously published data.

PubMed: 21697598
DOI: 10.1107/S0907444911015605

Experimental method

X-RAY DIFFRACTION (1.1 Å)