3LKJ

Small Molecule Inhibition of the TNF Family Cyokine CD40 Ligand Through a Subunit Fracture Mechanism

3LKJ の概要

• エントリーDOI: 10.2210/pdb3lkj/pdb
• 分子名称: CD40 ligand, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2R)-{[(2'-[(biphenyl-3-ylmethyl)carbamoyl]-6'-{[(2R)-2-(pyrrolidin-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-6-{[(2R)-2-(1H-pyrrol-1-ylmethyl)pyrrolidin-1-yl]carbonyl}-4,4'-bipyridin-2-yl)carbonyl]amino}(cyclohexyl)ethanoic acid, ... (4 entities in total)
• 機能のキーワード: cd40l, cd154, tnf-family cytokine, protein-protein interaction, cell membrane, cytokine, disease mutation, disulfide bond, glycoprotein, membrane, phosphoprotein, secreted, signal-anchor, transmembrane
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 3
• 化学式量合計: 48136.33

構造登録者

Silvian, L.F.,Whitty, A. (登録日: 2010-01-27, 公開日: 2011-02-02, 最終更新日: 2023-09-06)

• 主引用文献: Silvian, L.F.,Friedman, J.E.,Strauch, K.,Cachero, T.G.,Day, E.S.,Qian, F.,Cunningham, B.,Fung, A.,Sun, L.,Su, L.,Zheng, Z.,Kumaravel, G.,Whitty, A.; Small Molecule Inhibition of the TNF Family Cytokine CD40 Ligand through a Subunit Fracture Mechanism.; Acs Chem.Biol., 6:636-647, 2011; PubMed: 21417339; DOI: 10.1021/cb2000346

実験手法

X-RAY DIFFRACTION (2.5 Å)