3LJD

The X-ray structure of zebrafish RNase1 from a new crystal form at pH 4.5

3LJD の概要

• エントリーDOI: 10.2210/pdb3ljd/pdb
• 関連するPDBエントリー: 2VQ8 2VQ9 3LJE 3LN8
• 分子名称: Zebrafish RNase1, SULFATE ION, ACETATE ION, ... (4 entities in total)
• 機能のキーワード: angiogenins, fish rnases, hydrolase
• 由来する生物種: Danio rerio (zebrafish)
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 29534.29

構造登録者

Russo Krauss, I.,Merlino, A.,Mazzarella, L.,Sica, F. (登録日: 2010-01-26, 公開日: 2010-12-08, 最終更新日: 2024-10-16)

主引用文献

Pizzo, E.,Merlino, A.,Turano, M.,Russo Krauss, I.,Coscia, F.,Zanfardino, A.,Varcamonti, M.,Furia, A.,Giancola, C.,Mazzarella, L.,Sica, F.,D'Alessio, G.
A new RNase sheds light on the RNase/angiogenin subfamily from zebrafish.
Biochem.J., 433:345-355, 2010

PubMed Abstract: Recently, extracellular RNases of the RNase A superfamily, with the characteristic CKxxNTF sequence signature, have been identified in fish. This has led to the recognition that these RNases are present in the whole vertebrate subphylum. In fact, they comprise the only enzyme family unique to vertebrates. Four RNases from zebrafish (Danio rerio) have been previously reported and have a very low RNase activity; some of these are endowed, like human angiogenin, with powerful angiogenic and bactericidal activities. In the present paper, we report the three-dimensional structure, the thermodynamic behaviour and the biological properties of a novel zebrafish RNase, ZF-RNase-5. The investigation of its structural and functional properties, extended to all other subfamily members, provides an inclusive description of the whole zebrafish RNase subfamily.

PubMed: 21050179
DOI: 10.1042/BJ20100892

実験手法

X-RAY DIFFRACTION (1.38 Å)