3LIZ

crystal structure of bla g 2 complexed with Fab 4C3

Summary for 3LIZ

• Entry DOI: 10.2210/pdb3liz/pdb
• Related: 2NR6
• Descriptor: Aspartic protease Bla g 2, 4C3 monoclonal antibody Light Chain, 4C3 monoclonal antibody Heavy Chain, ... (9 entities in total)
• Functional Keywords: hydrolase-immune system complex, hydrolase/immune system
• Biological source: Blattella germanica (German cockroach); More
• Total number of polymer chains: 3
• Total formula weight: 89183.18

Authors

Li, M.,Gustchina, A.,Glesner, J.,Wunschmann, S.,Pomes, A.,Wlodawer, A. (deposition date: 2010-01-25, release date: 2010-12-15, Last modification date: 2024-11-27)

Primary citation

Glesner, J.,Wunschmann, S.,Li, M.,Gustchina, A.,Wlodawer, A.,Himly, M.,Chapman, M.D.,Pomes, A.
Mechanisms of allergen-antibody interaction of cockroach allergen Bla g 2 with monoclonal antibodies that inhibit IgE antibody binding.
Plos One, 6:e22223-e22223, 2011

PubMed Abstract: Cockroach allergy is strongly associated with asthma, and involves the production of IgE antibodies against inhaled allergens. Reports of conformational epitopes on inhaled allergens are limited. The conformational epitopes for two specific monoclonal antibodies (mAb) that interfere with IgE antibody binding were identified by X-ray crystallography on opposite sites of the quasi-symmetrical cockroach allergen Bla g 2.

PubMed: 21789239
DOI: 10.1371/journal.pone.0022223

Experimental method

X-RAY DIFFRACTION (1.8 Å)