3LGZ

Crystal structure of dehydrosqualene synthase Y129A from S. aureus complexed with presqualene pyrophosphate

3LGZ の概要

• エントリーDOI: 10.2210/pdb3lgz/pdb
• 分子名称: Dehydrosqualene synthase, {(1R,2R,3R)-2-[(3E)-4,8-dimethylnona-3,7-dien-1-yl]-2-methyl-3-[(1E,5E)-2,6,10-trimethylundeca-1,5,9-trien-1-yl]cyclopropyl}methyl trihydrogen diphosphate, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: c30 carotenoid, virulence factor, presqualene diphosphate, pspp, transferase
• 由来する生物種: Staphylococcus aureus
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 35330.69

構造登録者

Lin, F.-Y.,Liu, Y.-L.,Liu, C.-I.,Wang, A.H.J.,Oldfield, E. (登録日: 2010-01-21, 公開日: 2010-12-22, 最終更新日: 2023-09-06)

• 主引用文献: Lin, F.Y.,Liu, C.I.,Liu, Y.L.,Zhang, Y.,Wang, K.,Jeng, W.Y.,Ko, T.P.,Cao, R.,Wang, A.H.,Oldfield, E.; Mechanism of action and inhibition of dehydrosqualene synthase.; Proc.Natl.Acad.Sci.USA, 107:21337-21342, 2010; PubMed: 21098670; DOI: 10.1073/pnas.1010907107

実験手法

X-RAY DIFFRACTION (2.41 Å)