3LEO

Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione

Summary for 3LEO

• Entry DOI: 10.2210/pdb3leo/pdb
• Related: 2UUH
• Descriptor: Leukotriene C4 synthase, PALMITOLEIC ACID, PALMITIC ACID, ... (9 entities in total)
• Functional Keywords: leukotriene c4 synthase, endoplasmic reticulum, leukotriene biosynthesis, lyase, membrane, nucleus, transmembrane
• Biological source: Homo sapiens
• Cellular location: Nucleus outer membrane; Multi-pass membrane protein: Q16873
• Total number of polymer chains: 1
• Total formula weight: 20518.19

Authors

Niegowski, D.,Martinez-Molina, D.,Rinaldo-Matthis, A.,Nordlund, P.,Haeggstrom, J. (deposition date: 2010-01-15, release date: 2010-10-27, Last modification date: 2023-09-06)

• Primary citation: Rinaldo-Matthis, A.,Wetterholm, A.,Martinez Molina, D.,Holm, J.,Niegowski, D.,Ohlson, E.,Nordlund, P.,Morgenstern, R.,Haeggstrom, J.Z.; Arginine 104 is a key catalytic residue in leukotriene C4 synthase.; J.Biol.Chem., 285:40771-40776, 2010; PubMed: 20980252; DOI: 10.1074/jbc.M110.105940

Experimental method

X-RAY DIFFRACTION (2.1 Å)