3LEO

Structure of human Leukotriene C4 synthase mutant R31Q in complex with glutathione

Entity

Entity ID	Chain ID	Description	Type	Chain length	Formula weight	Number of molecules	DB Name (Accession)	Biological source	Descriptive keywords
1	A	Leukotriene C4 synthase	polymer	155	17251.3	1	UniProt (Q16873) Pfam (PF01124) In PDB	Homo sapiens	LTC4 synthase, Leukotriene-C(4) synthase
2	A	PALMITOLEIC ACID	non-polymer		254.4	2	Chemie (PAM)
3	A	PALMITIC ACID	non-polymer		256.4	6	Chemie (PLM)
4	A	SULFATE ION	non-polymer		96.1	2	Chemie (SO4)
5	A	NICKEL (II) ION	non-polymer		58.7	2	Chemie (NI)
6	A	GLUTATHIONE	non-polymer		307.3	1	Chemie (GSH)
7	A	DODECYL-BETA-D-MALTOSIDE	non-polymer		510.6	1	Chemie (LMT)
8	A	GLYCEROL	non-polymer		92.1	1	Chemie (GOL)
9		water	water		18.0	76	Chemie (HOH)

Sequence modifications

A: 2 - 150 (UniProt: Q16873)

PDB	External Database	Details
His -4	-	expression tag
His -3	-	expression tag
His -2	-	expression tag
His -1	-	expression tag
His 0	-	expression tag
His 1	-	expression tag
Gln 31	Arg 31	engineered mutation

Contents of the asymmetric unit

Polymers	Number of chains	1
	Total formula weight	17251.3
Non-Polymers*	Number of molecules	15
	Total formula weight	3266.9
All*	Total formula weight	20518.2

*Water molecules are not included.