3LEE

Crystal structure of the human squalene synthase complexed with BPH-652

3LEE の概要

• エントリーDOI: 10.2210/pdb3lee/pdb
• 分子名称: Squalene synthetase, (1R)-4-(3-phenoxyphenyl)-1-phosphonobutane-1-sulfonic acid, MAGNESIUM ION, ... (4 entities in total)
• 機能のキーワード: transferase, isoprenoid synthase fold, cholesterol biosynthesis, endoplasmic reticulum, isoprene biosynthesis, lipid synthesis, magnesium, membrane, multifunctional enzyme, nadp, oxidoreductase, steroid biosynthesis, sterol biosynthesis, transmembrane
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Endoplasmic reticulum membrane; Multi-pass membrane protein: P37268
• タンパク質・核酸の鎖数: 6
• 化学式量合計: 237464.17

構造登録者

Liu, Y.-L.,Lin, F.-Y.,Oldfield, E. (登録日: 2010-01-14, 公開日: 2010-12-08, 最終更新日: 2024-02-21)

• 主引用文献: Lin, F.-Y.,Liu, C.-I.,Liu, Y.-L.,Zhang, Y.,Wang, K.,Cao, R.,Wang, A.H.J.,Oldfield, E.; Mechanism of Action (and Inhibition) of Head-to-Head Terpene Synthases: A Structural Investigation; To be Published,

実験手法

X-RAY DIFFRACTION (3.2 Å)