3LC3
Benzothiophene Inhibitors of Factor IXa
Summary for 3LC3
Entry DOI | 10.2210/pdb3lc3/pdb |
Related | 3LC5 |
Descriptor | Coagulation factor IX, 1-[5-(3,4-dimethoxyphenyl)-1-benzothiophen-2-yl]methanediamine, CALCIUM ION, ... (5 entities in total) |
Functional Keywords | protein-inhibitor complex, peptidase s1, blood coagulation, calcium, cleavage on pair of basic residues, disease mutation, disulfide bond, egf-like domain, gamma-carboxyglutamic acid, glycoprotein, hemophilia, hydrolase, hydroxylation, pharmaceutical, phosphoprotein, polymorphism, protease, secreted, serine protease, sulfation, zymogen, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) More |
Cellular location | Secreted: P00740 P00740 |
Total number of polymer chains | 4 |
Total formula weight | 66231.67 |
Authors | |
Primary citation | Wang, S.,Beck, R.,Blench, T.,Burd, A.,Buxton, S.,Malic, M.,Ayele, T.,Shaikh, S.,Chahwala, S.,Chander, C.,Holland, R.,Merette, S.,Zhao, L.,Blackney, M.,Watts, A. Studies of Benzothiophene Template as Potent Factor IXa (FIXa) Inhibitors in Thrombosis. J.Med.Chem., 53:1465-1472, 2010 Cited by PubMed: 20121198DOI: 10.1021/jm901475e PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.9 Å) |
Structure validation
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