3LC3
Benzothiophene Inhibitors of Factor IXa
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A, C (A, C) | Coagulation factor IX | polymer | 235 | 26190.8 | 2 | UniProt (P00740) Pfam (PF00089) | Homo sapiens (human) | Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain |
| 2 | B, D (B, D) | Coagulation factor IX | polymer | 57 | 6256.1 | 2 | UniProt (P00740) Pfam (PF14670) | Homo sapiens (human) | Christmas factor, Plasma thromboplastin component, PTC, Coagulation factor IXa light chain, Coagulation factor IXa heavy chain |
| 3 | E, F, H, I (A, C) | 1-[5-(3,4-dimethoxyphenyl)-1-benzothiophen-2-yl]methanediamine | non-polymer | 314.4 | 4 | Chemie (IYX) | |||
| 4 | G, J (A, C) | CALCIUM ION | non-polymer | 40.1 | 2 | Chemie (CA) | |||
| 5 | K, L, M, N (A, B, C, D) | water | water | 18.0 | 420 | Chemie (HOH) |
Sequence modifications
B, D: 87 - 142 (UniProt: P00740)
| PDB | External Database | Details |
|---|---|---|
| Met 86 | - | initiating methionine |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 4 |
| Total formula weight | 64893.9 | |
| Non-Polymers* | Number of molecules | 6 |
| Total formula weight | 1337.8 | |
| All* | Total formula weight | 66231.7 |
