3LAM

Crystal structure of HIV-1 reverse transcriptase in complex with N1-propyl pyrimidinedione non-nucleoside inhibitor

3LAM の概要

• エントリーDOI: 10.2210/pdb3lam/pdb
• 関連するPDBエントリー: 3LAK 3LAL 3LAN
• 分子名称: HIV Reverse transcriptase, 3-methyl-5-{[5-(1-methylethyl)-2,6-dioxo-3-propyl-1,2,3,6-tetrahydropyrimidin-4-yl]carbonyl}benzonitrile, SULFATE ION, ... (4 entities in total)
• 機能のキーワード: hiv, rt, nnrti, transferase
• 由来する生物種: Human immunodeficiency virus type 1 (HIV-1)
• 細胞内の位置: Matrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 129945.60

構造登録者

Lansdon, E.B.,Mitchell, M.L. (登録日: 2010-01-06, 公開日: 2010-02-23, 最終更新日: 2023-09-06)

• 主引用文献: Mitchell, M.L.,Son, J.C.,Guo, H.,Im, Y.A.,Cho, E.J.,Wang, J.,Hayes, J.,Wang, M.,Paul, A.,Lansdon, E.B.,Chen, J.M.,Graupe, D.,Rhodes, G.,He, G.X.,Geleziunas, R.,Xu, L.,Kim, C.U.; N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.; Bioorg.Med.Chem.Lett., 20:1589-1592, 2010; PubMed: 20138513; DOI: 10.1016/j.bmcl.2010.01.085

実験手法

X-RAY DIFFRACTION (2.76 Å)