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3LAN

Crystal structure of HIV-1 reverse transcriptase in complex with N1-butyl pyrimidinedione non-nucleoside inhibitor

Summary for 3LAN
Entry DOI10.2210/pdb3lan/pdb
Related3LAK 3LAL 3LAM
DescriptorHIV Reverse transcriptase, 3-{[3-butyl-5-(1-methylethyl)-2,6-dioxo-1,2,3,6-tetrahydropyrimidin-4-yl]carbonyl}-5-methylbenzonitrile, SULFATE ION, ... (4 entities in total)
Functional Keywordshiv, reverse transcriptase, rt, nnrti, transferase
Biological sourceHuman immunodeficiency virus type 1 (HIV-1)
Cellular locationMatrix protein p17: Virion (Potential). Capsid protein p24: Virion (Potential). Nucleocapsid protein p7: Virion (Potential). Reverse transcriptase/ribonuclease H: Virion (Potential). Integrase: Virion (Potential): P04585
Total number of polymer chains2
Total formula weight130055.69
Authors
Lansdon, E.B.,Mitchell, M.L. (deposition date: 2010-01-06, release date: 2010-02-23, Last modification date: 2023-09-06)
Primary citationMitchell, M.L.,Son, J.C.,Guo, H.,Im, Y.A.,Cho, E.J.,Wang, J.,Hayes, J.,Wang, M.,Paul, A.,Lansdon, E.B.,Chen, J.M.,Graupe, D.,Rhodes, G.,He, G.X.,Geleziunas, R.,Xu, L.,Kim, C.U.
N1-Alkyl pyrimidinediones as non-nucleoside inhibitors of HIV-1 reverse transcriptase.
Bioorg.Med.Chem.Lett., 20:1589-1592, 2010
Cited by
PubMed: 20138513
DOI: 10.1016/j.bmcl.2010.01.085
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.55 Å)
Structure validation

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