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3L8V

Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor

Summary for 3L8V
Entry DOI10.2210/pdb3l8v/pdb
DescriptorHepatocyte growth factor receptor, 2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-N-(2,4-difluorophenyl)pyridine-3-carboxamide (3 entities in total)
Functional Keywordsreceptor tyrosine kinase, signal transduction, grb2, shc, atp-binding, glycoprotein, membrane, nucleotide-binding, phosphoprotein, proto-oncogene, transferase, transmembrane, tyrosine-protein kinase, alternative splicing, chromosomal rearrangement, disease mutation, kinase, polymorphism, receptor
Biological sourceHomo sapiens (human)
Cellular locationMembrane; Single-pass type I membrane protein. Isoform 3: Secreted: P08581
Total number of polymer chains1
Total formula weight35886.43
Authors
Sack, J. (deposition date: 2010-01-04, release date: 2010-05-05, Last modification date: 2023-09-06)
Primary citationWilliams, D.K.,Chen, X.T.,Tarby, C.,Kaltenbach, R.,Cai, Z.W.,Tokarski, J.S.,An, Y.,Sack, J.S.,Wautlet, B.,Gullo-Brown, J.,Henley, B.J.,Jeyaseelan, R.,Kellar, K.,Manne, V.,Trainor, G.L.,Lombardo, L.J.,Fargnoli, J.,Borzilleri, R.M.
Design, synthesis and structure-activity relationships of novel biarylamine-based Met kinase inhibitors.
Bioorg.Med.Chem.Lett., 20:2998-3002, 2010
Cited by
PubMed: 20382527
DOI: 10.1016/j.bmcl.2010.01.042
PDB entries with the same primary citation
Experimental method
X-RAY DIFFRACTION (2.4 Å)
Structure validation

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