3L8V
Crystal structure of the tyrosine kinase domain of the hepatocyte growth factor receptor C-MET in complex with a biarylamine based inhibitor
Entity
| Entity ID | Chain ID | Description | Type | Chain length | Formula weight | Number of molecules | DB Name (Accession) | Biological source | Descriptive keywords |
| 1 | A | Hepatocyte growth factor receptor | polymer | 314 | 35435.0 | 1 | UniProt (P08581) Pfam (PF07714) In PDB | Homo sapiens (human) | HGF receptor, Scatter factor receptor, SF receptor, HGF/SF receptor, Met proto-oncogene tyrosine kinase, c-Met |
| 2 | A | 2-({4-[(2-aminopyridin-4-yl)oxy]-3-fluorophenyl}amino)-N-(2,4-difluorophenyl)pyridine-3-carboxamide | non-polymer | 451.4 | 1 | Chemie (L8V) | |||
| 3 | water | water | 18.0 | 100 | Chemie (HOH) |
Sequence modifications
A: 1049 - 1360 (UniProt: P08581)
| PDB | External Database | Details |
|---|---|---|
| Gly 1047 | - | expression tag |
| Ala 1048 | - | expression tag |
| Phe 1194 | Tyr 1194 | engineered mutation |
| Phe 1234 | Tyr 1234 | engineered mutation |
| Asp 1235 | Tyr 1235 | engineered mutation |
Sequence viewer
Contents of the asymmetric unit
| Polymers | Number of chains | 1 |
| Total formula weight | 35435.0 | |
| Non-Polymers* | Number of molecules | 1 |
| Total formula weight | 451.4 | |
| All* | Total formula weight | 35886.4 |
