3L8S

Human p38 MAP Kinase in Complex with CP-547632

3L8S の概要

• エントリーDOI: 10.2210/pdb3l8s/pdb
• 関連するPDBエントリー: 3HUB 3HUC
• 分子名称: Mitogen-activated protein kinase 14, octyl beta-D-glucopyranoside, 3-[(4-bromo-2,6-difluorobenzyl)oxy]-5-{[(4-pyrrolidin-1-ylbutyl)carbamoyl]amino}isothiazole-4-carboxamide, ... (4 entities in total)
• 機能のキーワード: dfg-out, glycine-rich loop, cp-547632, alternative splicing, atp-binding, cytoplasm, kinase, nucleotide-binding, nucleus, phosphoprotein, polymorphism, serine/threonine-protein kinase, transferase
• 由来する生物種: Homo sapiens (human)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 42059.74

構造登録者

Gruetter, C.,Simard, J.R.,Rauh, D. (登録日: 2010-01-03, 公開日: 2010-03-09, 最終更新日: 2024-02-21)

• 主引用文献: Simard, J.R.,Getlik, M.,Grutter, C.,Schneider, R.,Wulfert, S.,Rauh, D.; Fluorophore labeling of the glycine-rich loop as a method of identifying inhibitors that bind to active and inactive kinase conformations.; J.Am.Chem.Soc., 132:4152-4160, 2010; PubMed: 20201574; DOI: 10.1021/ja908083e

実験手法

X-RAY DIFFRACTION (2.35 Å)