3L7C

Crystal Structure of Glycogen Phosphorylase DK4 complex

3L7C の概要

• エントリーDOI: 10.2210/pdb3l7c/pdb
• 関連するPDBエントリー: 3L79 3L7A 3L7B 3L7D
• 分子名称: Glycogen phosphorylase, muscle form, 1-(3-deoxy-3-fluoro-beta-D-glucopyranosyl)-5-fluoropyrimidine-2,4(1H,3H)-dione (3 entities in total)
• 機能のキーワード: glycogenolysis, type 2 diabetes, allosteric enzyme, carbohydrate metabolism, glycogen metabolism, glycosyltransferase, nucleotide-binding, phosphorylation, pyridoxal phosphate, transferase, phosphoprotein
• 由来する生物種: Oryctolagus cuniculus (European rabbit,Japanese white rabbit,domestic rabbit,rabbits)
• タンパク質・核酸の鎖数: 1
• 化学式量合計: 97944.73

構造登録者

Tsirkone, V.G.,Lamprakis, C.,Hayes, J.M.,Skamnaki, V.,Drakou, C.,Zographos, S.E.,Leonidas, D.D. (登録日: 2009-12-28, 公開日: 2010-10-20, 最終更新日: 2023-11-22)

• 主引用文献: Tsirkone, V.G.,Tsoukala, E.,Lamprakis, C.,Manta, S.,Hayes, J.M.,Skamnaki, V.T.,Drakou, C.,Zographos, S.E.,Komiotis, D.,Leonidas, D.D.; 1-(3-Deoxy-3-fluoro-beta-d-glucopyranosyl) pyrimidine derivatives as inhibitors of glycogen phosphorylase b: Kinetic, crystallographic and modelling studies.; Bioorg.Med.Chem., 18:3413-3425, 2010; PubMed: 20430629; DOI: 10.1016/j.bmc.2010.04.004

実験手法

X-RAY DIFFRACTION (1.93 Å)