3L4K
Topoisomerase II-DNA cleavage complex, metal-bound
Summary for 3L4K
Entry DOI | 10.2210/pdb3l4k/pdb |
Related | 3L4J |
Descriptor | DNA topoisomerase 2, DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... (8 entities in total) |
Functional Keywords | topoisomerase, protein-dna complex, covalently linked complex, dna supercoiling, dna replication, atp-binding, dna-binding, isomerase, nucleotide-binding, nucleus, phosphoprotein, isomerase-dna complex, isomerase/dna |
Biological source | Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast) |
Total number of polymer chains | 5 |
Total formula weight | 104469.91 |
Authors | Schmidt, B.H.,Burgin, A.B.,Deweese, J.E.,Osheroff, N.,Berger, J.M. (deposition date: 2009-12-20, release date: 2010-05-26, Last modification date: 2023-11-22) |
Primary citation | Schmidt, B.H.,Burgin, A.B.,Deweese, J.E.,Osheroff, N.,Berger, J.M. A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases. Nature, 465:641-644, 2010 Cited by PubMed: 20485342DOI: 10.1038/nature08974 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (2.98 Å) |
Structure validation
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