3L4K

Topoisomerase II-DNA cleavage complex, metal-bound

3L4K の概要

• エントリーDOI: 10.2210/pdb3l4k/pdb
• 関連するPDBエントリー: 3L4J
• 分子名称: DNA topoisomerase 2, DNA (5'-D(P*CP*CP*TP*AP*CP*TP*GP*CP*TP*AP*C)-3'), DNA (5'-D(*CP*GP*CP*GP*GP*TP*AP*GP*CP*AP*GP*TP*AP*GP*G)-3'), ... (8 entities in total)
• 機能のキーワード: topoisomerase, protein-dna complex, covalently linked complex, dna supercoiling, dna replication, atp-binding, dna-binding, isomerase, nucleotide-binding, nucleus, phosphoprotein, isomerase-dna complex, isomerase/dna
• 由来する生物種: Saccharomyces cerevisiae (brewer's yeast,lager beer yeast,yeast)
• タンパク質・核酸の鎖数: 5
• 化学式量合計: 104469.91

構造登録者

Schmidt, B.H.,Burgin, A.B.,Deweese, J.E.,Osheroff, N.,Berger, J.M. (登録日: 2009-12-20, 公開日: 2010-05-26, 最終更新日: 2023-11-22)

• 主引用文献: Schmidt, B.H.,Burgin, A.B.,Deweese, J.E.,Osheroff, N.,Berger, J.M.; A novel and unified two-metal mechanism for DNA cleavage by type II and IA topoisomerases.; Nature, 465:641-644, 2010; PubMed: 20485342; DOI: 10.1038/nature08974

実験手法

X-RAY DIFFRACTION (2.98 Å)