3L27

Crystal structure of Zaire Ebola VP35 interferon inhibitory domain R312A mutant

Summary for 3L27

Entry DOI	10.2210/pdb3l27/pdb
Related	3FKE 3L25 3L26 3L28 3L29 3L2A
Descriptor	Polymerase cofactor VP35, CHLORIDE ION, PHOSPHATE ION, ... (7 entities in total)
Functional Keywords	rna binding domain, interferon antiviral evasion, rna replication, rna-binding protein, transcription, host cytoplasm, interferon antiviral system evasion, rna-binding, virion, rna binding protein
Biological source	Zaire ebolavirus (ZEBOV)
Cellular location	Virion: Q05127
Total number of polymer chains	4
Total formula weight	58587.22
Authors	Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K. (deposition date: 2009-12-14, release date: 2010-01-26, Last modification date: 2023-09-06)
Primary citation	Leung, D.W.,Prins, K.C.,Borek, D.M.,Farahbakhsh, M.,Tufariello, J.M.,Ramanan, P.,Nix, J.C.,Helgeson, L.A.,Otwinowski, Z.,Honzatko, R.B.,Basler, C.F.,Amarasinghe, G.K. Structural basis for dsRNA recognition and interferon antagonism by Ebola VP35. Nat.Struct.Mol.Biol., 17:165-172, 2010 Cited by PubMed: 20081868 DOI: 10.1038/nsmb.1765 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (1.95 Å)

Structure validation