3L0V
Crystal structure of catalytic domain of TACE with the first hydantoin inhibitor occupying the S1' pocket
Summary for 3L0V
Entry DOI | 10.2210/pdb3l0v/pdb |
Related | 1bkc 3KMC 3L0T 3LE9 3LEA |
Descriptor | Disintegrin and metalloproteinase domain-containing protein 17, ZINC ION, (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-methylimidazolidine-2,4-dione, ... (4 entities in total) |
Functional Keywords | metal-binding, metalloprotease, notch signaling pathway, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor |
Biological source | Homo sapiens (human) |
Cellular location | Membrane; Single-pass type I membrane protein: P78536 |
Total number of polymer chains | 2 |
Total formula weight | 61849.64 |
Authors | Orth, P. (deposition date: 2009-12-10, release date: 2010-03-02, Last modification date: 2023-09-06) |
Primary citation | Yu, W.,Guo, Z.,Orth, P.,Madison, V.,Chen, L.,Dai, C.,Feltz, R.J.,Girijavallabhan, V.M.,Kim, S.H.,Kozlowski, J.A.,Lavey, B.J.,Li, D.,Lundell, D.,Niu, X.,Piwinski, J.J.,Popovici-Muller, J.,Rizvi, R.,Rosner, K.E.,Shankar, B.B.,Shih, N.Y.,Siddiqui, M.A.,Sun, J.,Tong, L.,Umland, S.,Wong, M.K.,Yang, D.Y.,Zhou, G. Discovery and SAR of hydantoin TACE inhibitors. Bioorg.Med.Chem.Lett., 20:1877-1880, 2010 Cited by PubMed: 20172725DOI: 10.1016/j.bmcl.2010.01.148 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.75 Å) |
Structure validation
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