3L0V

Crystal structure of catalytic domain of TACE with the first hydantoin inhibitor occupying the S1' pocket

3L0V の概要

• エントリーDOI: 10.2210/pdb3l0v/pdb
• 関連するPDBエントリー: 1bkc 3KMC 3L0T 3LE9 3LEA
• 分子名称: Disintegrin and metalloproteinase domain-containing protein 17, ZINC ION, (5R)-5-[(5-methoxy-3-oxo-1,3-dihydro-2H-indazol-2-yl)methyl]-5-methylimidazolidine-2,4-dione, ... (4 entities in total)
• 機能のキーワード: metal-binding, metalloprotease, notch signaling pathway, protease, hydrolase-hydrolase inhibitor complex, hydrolase/hydrolase inhibitor
• 由来する生物種: Homo sapiens (human)
• 細胞内の位置: Membrane; Single-pass type I membrane protein: P78536
• タンパク質・核酸の鎖数: 2
• 化学式量合計: 61849.64

構造登録者

Orth, P. (登録日: 2009-12-10, 公開日: 2010-03-02, 最終更新日: 2023-09-06)

• 主引用文献: Yu, W.,Guo, Z.,Orth, P.,Madison, V.,Chen, L.,Dai, C.,Feltz, R.J.,Girijavallabhan, V.M.,Kim, S.H.,Kozlowski, J.A.,Lavey, B.J.,Li, D.,Lundell, D.,Niu, X.,Piwinski, J.J.,Popovici-Muller, J.,Rizvi, R.,Rosner, K.E.,Shankar, B.B.,Shih, N.Y.,Siddiqui, M.A.,Sun, J.,Tong, L.,Umland, S.,Wong, M.K.,Yang, D.Y.,Zhou, G.; Discovery and SAR of hydantoin TACE inhibitors.; Bioorg.Med.Chem.Lett., 20:1877-1880, 2010; PubMed: 20172725; DOI: 10.1016/j.bmcl.2010.01.148

実験手法

X-RAY DIFFRACTION (1.75 Å)