3KZ8
Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs (p53-DNA complex 3)
Summary for 3KZ8
Entry DOI | 10.2210/pdb3kz8/pdb |
Related | 3IGK 3IGL |
Descriptor | Cellular tumor antigen p53, DNA (5'-D(*TP*GP*GP*GP*CP*AP*TP*GP*CP*CP*CP*GP*GP*GP*CP*AP*TP*GP*CP*CP*C)-3'), ZINC ION, ... (5 entities in total) |
Functional Keywords | p53, mutant protein, loop-sheet-helix motif, dna target, activator, anti-oncogene apoptosis, cell cycle, covalent protein-rna linkage, disease mutation, dna-binding, endoplasmic reticulum, glycoprotein, host-virus interaction, li-fraumeni syndrome, methylation, nucleus, phosphoprotein, transcription, transcription regulation, transcription/dna comple, apoptosis, isopeptide bond, tumor suppressor, transcription-dna complex, transcription/dna |
Biological source | Homo sapiens (human) More |
Cellular location | Cytoplasm. Isoform 1: Nucleus. Isoform 2: Nucleus. Isoform 3: Nucleus. Isoform 4: Nucleus. Isoform 7: Nucleus. Isoform 8: Nucleus. Isoform 9: Cytoplasm: P04637 |
Total number of polymer chains | 3 |
Total formula weight | 51836.92 |
Authors | Rozenberg, H.,Suad, O.,Shakked, Z. (deposition date: 2009-12-08, release date: 2010-03-31, Last modification date: 2023-11-01) |
Primary citation | Kitayner, M.,Rozenberg, H.,Rohs, R.,Suad, O.,Rabinovich, D.,Honig, B.,Shakked, Z. Diversity in DNA recognition by p53 revealed by crystal structures with Hoogsteen base pairs Nat.Struct.Mol.Biol., 17:423-429, 2010 Cited by PubMed: 20364130DOI: 10.1038/nsmb.1800 PDB entries with the same primary citation |
Experimental method | X-RAY DIFFRACTION (1.91 Å) |
Structure validation
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