3KWJ

Structure of human DPP-IV with (2S,3S,11bS)-3-(3-Fluoromethyl-phenyl)-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-ylamine

Summary for 3KWJ

Entry DOI	10.2210/pdb3kwj/pdb
Related	1NU6 1NU8 3KWF 3KWH
Descriptor	Dipeptidyl peptidase 4 soluble form, 2-acetamido-2-deoxy-beta-D-glucopyranose, (2S,3S,11bS)-3-[3-(fluoromethyl)phenyl]-9,10-dimethoxy-1,3,4,6,7,11b-hexahydro-2H-pyrido[2,1-a]isoquinolin-2-amine, ... (4 entities in total)
Functional Keywords	diabetes type ii, aminopeptidase, cell membrane, disulfide bond, glycoprotein, hydrolase, membrane, protease, secreted, serine protease, signal-anchor, transmembrane
Biological source	Homo sapiens (human)
Total number of polymer chains	2
Total formula weight	170550.99
Authors	Hennig, M.,Stihle, M.,Thoma, R. (deposition date: 2009-12-01, release date: 2010-09-15, Last modification date: 2020-09-09)
Primary citation	Boehringer, M.,Fischer, H.,Hennig, M.,Hunziker, D.,Huwyler, J.,Kuhn, B.,Loeffler, B.M.,Luebbers, T.,Mattei, P.,Narquizian, R.,Sebokova, E.,Sprecher, U.,Wessel, H.P. Aryl- and heteroaryl-substituted aminobenzo[a]quinolizines as dipeptidyl peptidase IV inhibitors. Bioorg.Med.Chem.Lett., 20:1106-1108, 2010 Cited by PubMed: 20031408 DOI: 10.1016/j.bmcl.2009.12.025 PDB entries with the same primary citation
Experimental method	X-RAY DIFFRACTION (2.8 Å)

Structure validation